Tuesday, July 31, 2012

Attaining an Email List of Non Profit Organizations Productively | Pro ...

Finding an up-to-date list of non profit organizations is really challenging. Since most people have become used to attaining things immediately, manually compiling a list of non profit organizations is really the very last option. It is a must for everybody to know that they could already have got an email list of non profit organizations. E-mail lists are something that people should never ignore and consider as junk e-mail. An email list supplying the contacts and names of numerous non profit organizations is a simple way to get in touch with a non profit organization. It is less time consuming and affordable in anyone who has an interest in developing an ongoing communication with a specific organization. As there are plenty of existing non profit organizations at the present time, getting them on an e-mail list is truly a hassle free method of choosing the best organization that suits a person?s need. For as long as a web connection, a computer and an e-mail address are readily available, business along with non profit organizations is not really a challenge.

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List Of Non Profit OrganizationsMost of businesses, who?re operating to market goods or services into non profit organizations, discovered and verified that this strategy of e-mail marketing is an incredibly great way to improve sales rating. It will take a great hand and mind to create effective advertising mails for marketing purposes. Definitely, you can do the writing yourself, or if perhaps you are too busy, you might just hire professional writers to create mails for your ad and marketing strategy. The moment are all set, you can begin mailing e-mails to those people in your email list of non-profit organizations.? A catchy and informative email will absolutely hook your prospects? attentions. Be exact, direct, professional as well as friendly on your message. You don?t need to create expensive, too-good-to-be-real mails, for in most cases, the receiver would normally mark that kind of e-mail as spam. Since you?re about to purchase your leads, making use of your list of none profit organizations wisely.? Re-compose your messages every now and then to avoid being designated as spammer by the mailing sites.

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So what do I need to do with the email list of non profit organizations? Right now, you may not appreciate the significance of such list. But in the future, a list of non profit organizations on hand can assist you transform several goals perfectly into a reality. If you?re a writer or an advocate of any certain idea, funding is always on the top of your needs. Convincing someone to have faith in your capacity and your idea cannot be achieved overnight. So long as you have got a list of the non profit organizations which you could contact, you can update the organizations everyday of the things that you were able to complete and the activities that you have got in your mind. At first, these organizations may think that you are just someone who is attempting to gain something on your own. In the coming days or months, your regular conversation with them will let these organizations believe and understand in your ideas. It might appear impossible however it is a method that most successful writers and advocates have used. Give an updated email list a try to personally experience what exactly the list can do to you as well as your objectives.

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Most of non profit organizations nowadays utilize the internet to have interaction with their fellows as well as co-organizations. Hence then, they normally have e-mail addresses that they?d check out every now and then. Getting an email list of non-profit organizations could help you reach these broad viewers. Through sending emails to such organizations, you?re informing them as to what your company could offer. Email ad or promotional strategies are less expensive when compared with some other systems use to improve sales rating, and that is tested not only by small businesses but also by corporate businesses. Having a list of non profit organizations on your data base is just like getting followers for your particular item. Make use of your marketing secrets in order to catch your prospective customers and watch your sales rate improves.

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Getting an up-to-date list of non profit organizations is truly tough. Because most individuals have become used to achieving things in an instant, manually compiling a list of non profit organizations is surely the very last choice. It is advisable for anyone to know that they can already have got an email list of non profit organizations. Email lists are something that people shouldn?t ignore and regard as junk e-mail. An email list supplying the names and contacts of several non profit organizations is a simple way to get in contact with a non profit organization. It?s less time consuming and economical on anyone who has an interest in developing an ongoing communication with the specific organization. As there are many active non profit organizations right now, getting them in an e-mail list is certainly a hassle-free means of selecting the right organization that matches a person?s need. For as long as a net connection, a computer and an email address are on hand, business with non profit organizations is not an issue.

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Visit http://listofnonprofitorganizations.co if you would like to learn more.

Source: http://prolifetoolkit.com/attaining-an-email-list-of-non-profit-organizations-productively/

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Music Review: Santa Fe Chamber Music Festival in New Mexico

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Source: www.nytimes.com --- Monday, July 30, 2012
The pianist Magnus Lindberg, the clarinetist Chen Halevi and the Mir? Quartet performed at the Santa Fe Chamber Music Festival, in its 40th season, on Thursday. ...

Source: http://www.nytimes.com/2012/07/30/arts/music/santa-fe-chamber-music-festival-in-new-mexico.html

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Travel and Vacations | A Holiday Lodge ? A Home Away From Home

Holiday Lodges are always a choice of more and more popular, especially for families. Many vacationers want to save money and fly to a distant country, prefer off a growing number of families one or two weeks, but reached into the car. Holiday Lodge is usually cheaper than the working world to travel for a few weeks at the beach. Today the cottages are equipped with all modern comforts and offer an excellent alternative to the typical package holiday.

Family Vacation

A house is an ideal choice for a family outing, and it?s almost always cheaper than staying in a hotel. Like most lodges come with fully equipped kitchen or kitchenette at least you do not have to take for the whole family for a meal several times a day. You can do some of your meals at the inn, and you can eat when you feel like it. Families with young children or babies find it useful to have a kitchen and the opportunity to cook at least sometimes. You can travel with the children to make fun, but it is also tiring, and a place to stay, in addition to a more relaxing stay.

Romantic weekend

Holiday lodges are ideal for couples to spend a quiet weekend or a week. Many cabins are equipped with all modern amenities such as bathrooms, fireplaces, Jacuzzis, kitchens, spacious living areas and all the facilities you need for a short or long stay. Teams may be a quieter and more intimate than a hotel and apartments are great places for a romantic and relaxing. Remain

Outdoor Activities

Many holiday lodges are situated in the beautiful nature: in the picturesque countryside near beaches or mountains. There are many opportunities for outdoor activities like hiking, climbing, cycling, mountain biking, horseback riding, fishing and other outdoor sports. Whether a leisurely stroll or enjoy a week of work, you can find a vacation lodge near a great potential for outdoor sports. The landscape is one of the best people to stay in a lodge in the country.

Lodge Locations

Offers holiday houses in a quiet place where they are in parks Holiday Lodges offers a wide range of services and facilities you can find find. Many families can stay in a lodge park has activities for children and gives children the opportunity to meet other children. Holiday parks may provide facilities such as swimming pools, restaurants and bars, and they are often conveniently located near or close to major attractions picturesque nature. Whether you are looking for a romantic weekend with your loved one, a family trip somewhere fun or a holiday, allows you to walk, cycle or enjoy other outdoor activities can, of our Vacation Lodge is the ideal choice.

Source: http://www.natwatch.org/a-holiday-lodge-a-home-away-from-home

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Monday, July 30, 2012

Attendees Prepare Themselves for Changes to Health Care by ...

Boca Raton, FL, July 29, 2012 ?(PR.com)? The American Academy of Anti-Aging has wrapped up another successful event this past week. With an outstanding turnout, A4M continues to be the leaders in Anti-Aging, Regenerative, and Functional medicine. This event focused on Lifestyle Coaching and Metabolic Triad, both modules are paving the way for preventive measures of lifestyle disease and conditions, had hundreds in attendance.

?I attended the Lifestyle Health Coaching conference because I was interested in seeing if this would be a good career path for me to take. It will fit in nicely, as I work in a medical aesthetics office, where I will already have a client base, and eventually I plan on developing my own business. It was an awesome experience overall, and I came away with so much valuable information! I would recommend this to anyone, if it is offered in the future,? stated Erin Martin.

Under the Affordable Care Act, preventive services for screening for Obesity and counseling, Diet Counseling, screening for Type 2 Diabetes for individuals with high blood pressure, and Cholesterol screening for individuals of certain ages or at higher risk, must be covered without you having to pay a copayment or co-insurance or meet your deductible.

The practice of Functional medicine seeks to identify and address the root causes of disease, and views the body as one integrated system, not a collection of independent organs divided up by medical specialties. Functional medicine practitioners provide chronic care management with the belief that diet, nutrition, and exposure to environmental toxins play central roles in functional medicine because they may predispose to illness, provoke symptoms, and modulate the activity of biochemical mediators through a complex and diverse set of mechanisms.

?Module XX- Metabolic Triads was a professional experience that helped me learn facts, thought processes, and application of diagnosis and treatment protocols in functional/regenerative medicine, and each faculty member presented in a captivating way. They introduced the basics of each triad then moved into clinical presentations with signs and symptoms and tied in clinical pearls including how to teach patients about their chronic illness. This was by far one of the most rewarding seminars I have taken so far in my early career. The most beneficial and rewarding part for me was working up cases in small groups with the ability to present our findings and receive feedback from the faculty members,? stated Dr. Rudy Mueller.

There is a new wave of medicine on the horizon; it?s time to prepare for The Future of Medicine.

Contact Information:
The American Academy of Anti-Aging
Jonathan Marquez
561-997-0112
Contact via Email
www.a4m.com

Click here to read the full story: Attendees Prepare Themselves for Changes to Health Care by Continuing Education

Press Release Distributed by PR.com

Source: http://health.rambergmedia.com/attendees-prepare-themselves-for-changes-to-health-care-by-continuing-education/

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RBC Life Overview - ApostolicCM.com Answers

RBC Life is a wellness company headquartered out of Irving, Texas. For the last two decades, the company has centered on providing dermatological solutions using aloe. They also provide a network marketing opportunity for their products to interested representatives.

This is a brief overview of the company ? who they are, what they do, and whether this is actually a potentially lucrative opportunity or not.

The Company

RBC Life provides nutritional supplements and body care products. Over 20 years back, in the 1980?s, founder Clinton Howard began looking at the health benefits of aloe ? a plant that?s been used for centuries to cure such things as common sunburns, amongst others.

Howard formed a team to isolate the active ingredient in aloe, and then put that ingredient in a variety of skincare and health items. It took four many years, and $20 million dollars to find the proper information, but the company now sells a line of over 75 products which are based around that investigation.

This company is a little different from others in health and wellness because of their accreditations. Most network marketing companies that offer a type of wellness solution are based on vitamins and minerals that haven?t been scientifically which may ?cure? anything ? instead, they are just good for overall wellness. RBC Life belongs to accreditation organizations like the BBB, has Certified Organic products, and Vegan Certified too.

The RBC Life Opportunity

There are 3 ways to purchase RBC Life?s products. First, they will take upon retail customers straight from their website. Then, there are ?Preferred Customers? who can get 10-20% off of retail price simply by signing up, and applying for auto-ship services. Finally, there are ?Associates? that are people interested in becoming a member of the MLM opportunity. Associates get all items at wholesale price (20% from retail) and get access to the back office (free for the first year, $7. 95 per month after that) and a lot of other bonuses typically given in these types of opportunities ? bonuses, trips, expense accounts, etc.

Is RBC Life For You?

RBC Life offers higher quality products than many other network marketing opportunities. They have a large amount of accreditations, and although their items are spread out amongst a variety of cures (healthy residing, anti aging, energy and fitness, specific needs) they seem to be legitimate. One big complaint with the company, though, is the fact that their commission rate is really low ? meaning their wholesale prices are excessive. Reps have to sell lots of volume to do well.

At the end from the day, though, the most important point for new reps to know is that you have to know how to market products like these before you begin in on an opportunity.

Most people begin by leveraging their ?warm market? and contacting friends and family to join in on a great opportunity. But that?s the wrong way to go about it ? this particular warm market will fizzle, and reps are usually left frustrated.

It?s crucial to learn to use the internet to start building downlines and really making money from opportunities like RBC Life. Luckily, there are many places to understand and start building your business toolkit for RBC Life achievement.

rbclife.com

Source: http://answers.apostoliccm.com/2012/07/rbc-life-overview-a-more-detailed-look-at-rbc-lifes-occasion/

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China wins 2nd straight Olympic gold in gymnastics

LONDON (AP) ? No doubt about it, China is still No. 1 in men's gymnastics.

No. 2 took a little longer to figure out.

The Chinese won their second straight Olympic title and third in four games Monday, finishing with a score of 275.997 points.

Britain was initially announced as the silver medalist, setting off raucous celebrations at the O2 Arena. But Japan filed an inquiry over the score of three-time world champion Kohei Uchimura on pommel horse, the team's last routine. After judges spent about five minutes reviewing it, his score was revised and Japan was awarded the silver and Britain was bumped down to bronze.

The crowd booed, but any medal is a cause for celebration for the British men, who hadn't won one in a century.

The Americans, hoping for their first Olympic title since 1984 after finishing first in qualifying, finished fifth.

Source: http://news.yahoo.com/china-wins-2nd-straight-olympic-gold-gymnastics-182417406--oly.html

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Sunday, July 29, 2012

Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth

Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth [ Back to EurekAlert! ] Public release date: 29-Jul-2012
[ | E-mail | Share Share ]

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
61-705-734-170
Massachusetts Eye and Ear Infirmary

BOSTON (July 29, 2012) Researchers from the Massachusetts Eye and Ear Infirmary, The Children's Hospital of Philadelphia, Loyola University Chicago Health Sciences Division and their collaborators have isolated an elusive human gene that causes a common form of Leber congenital amaurosis (LCA), a relatively rare but devastating form of early-onset blindness. The new LCA gene is called NMNAT1. Finding the specific gene mutated in patients with LCA is the first step towards developing sight-saving gene therapy.

LCA is an inherited retinal degenerative disease characterized by reduced vision in infancy. Within the first few months of life, parents usually notice a lack of visual responsiveness and unusual roving eye movements known as nystagmus. LCA typically involves only vision problems, but can be accompanied by disease in other organ systems in a minority of patients. LCA is a common reason children are enrolled in schools for the blind.

"The immediate benefit of this discovery is that affected patients with mutations in this new LCA gene now know the cause of their condition," said Eric Pierce, M.D., Ph.D., co-senior author and director of the Ocular Genomics Institute at Mass. Eye and Ear. "Scientists now have another piece to the puzzle as to why some children are born with LCA and decreased vision. The long-term goal of our research is to develop therapies to limit or prevent vision loss from these disorders."

NMNAT1 is the 18th identified LCA gene. The gene resides in a region that was known to harbor an LCA gene since 2003, but the specific disease gene has been undiscovered until now. These findings will be published on July 29 in the online edition of Nature Genetics.

To identify NMNAT1, scientists performed whole exome sequencing of the family of two siblings who initially presented for evaluation of LCA but who had no mutations in any of the known LCA genes. Being seen by a multi-disciplinary team that took the case from careful clinical characterization to genetic testing to the research laboratory was an essential ingredient for success.

"By using whole exome sequencing, we found a mutation in a gene that no one could have predicted would be associated with LCA," said Dr. Pierce.

"Whereas most of the known LCA genes involve dysfunction of retinal ciliary proteins necessary for light detection in the eye, NMNAT1 is uniquely distinguished by being the first metabolic enzyme linked to LCA," said Marni J. Falk, M.D., co-first author and Clinical Geneticist at The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.

Having found a mutation in NMNAT1 in this one family, the investigators next asked if mutations in NMNAT1 also cause disease in other patients with LCA. Screening of 284 unrelated patients with LCA from the United States, England, France and India allowed them to identify 13 other patients with mutations in NMNAT1 as the cause of their disease.

Drs. Falk, Pierce and colleagues also studied how the identified mutations in NMNAT1 affect the function of the NMNAT1 protein, and thus may cause dysfunction and death of the light sensitive photoreceptor cells in the retina. Working together with Eiko Nakamaru-Ogiso, Ph.D., in the Department of Biochemistry and Biophysics at The University of Pennsylvania, they found that mutations in NMNAT1 appear to decrease the ability of the NMNAT1 protein to produce NAD+, a key mediator of cellular signaling and energetics.

Early treatment for patients with NMNAT1-related LCA could be especially beneficial.

Researchers found that all but the youngest patient with NMNAT1 mutations had damage to the macula, the center of the retina that is needed for central vision. "This 4-year-old girl who doesn't have central vision loss yet can possibly benefit substantially if we can devise a therapy for her NMNAT1-mediated LCA that prevents her from developing severe central vision loss," Dr. Pierce said.

This study is an example of the multidisciplinary collaboration among the three institutions, using exome sequencing to discover genes involved in inherited diseases caused by mutations of a single gene. "With the robust database and pipeline that we have developed, we have analyzed more than 300 whole exomes of patients and families with single-gene diseases," said Dr. Xiaowu Gai, co-senior author and director of the Center for Biomedical Informatics at Loyola University Chicago Stritch School of Medicine. "We are following up on a number of strong candidate genes. We are sequencing many new samples and expect similar exciting discoveries for other diseases."

###

About Massachusetts Eye and Ear

Mass. Eye and Ear clinicians and scientists are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. After uniting with Schepens Eye Research Institute in 2011, Mass. Eye and Ear in Boston became the world's largest vision and hearing research center, offering hope and healing to patients everywhere through discovery and innovation. Mass. Eye and Ear is a Harvard Medical School teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high-quality and affordable specialty care that ranges from the routine to the very complex. U.S. News & World Report's "Best Hospitals Survey" has consistently ranked the Mass. Eye and Ear Departments of Otolaryngology and Ophthalmology as top five in the nation. Mass. Eye and Ear is home to the Ocular Genomics Institute which aims to translate the promise of personalized genomic medicine into clinical care for ophthalmic disorders. For more information about life-changing care and research, or to learn how you can help, please visit MassEyeAndEar.org.

Grant support:

This work was supported by grants from the National Institutes of Health [RO1-EY12910 (E.A.P.), R03-DK082446 (M.J.F.), R01-GM097409 (E.N-O), P30HD026979 (M.J.F.,R.X.) and P30EY014104 (MEEI core support)]; the Foundation Fighting Blindness USA (I.A.,A.D.B.,E.L.B.,S.S.B.,Q.L.,A.T.M., D.S.M.,E.A.P., J-A.S.,S.M-S., A.R.W.); Rosanne Silbermann Foundation (E.A.P.); Penn Genome Frontiers Institute (E.A.P, X.G.); Institutional Fund to the Center for Biomedical Informatics by the Loyola University Stritch School of Medicine (X.G.); the Foerderer Award for Excellence from the Children's Hospital of Philadelphia (M.J.F. and X.G.); The Angelina Foundation Fund from the Division of Child Development and Metabolic Disease at The Children's Hospital of Philadelphia (M.J.F.); The Clinical and Translational Research Center at The Children's Hospital of Philadelphia (UL1-RR-024134) (M.J.F. and E.A.P.); the Department of Biotechnology, Government of India and the Champalimaud Foundation, Portugal (C.K); the Hyderabad Eye Research Foundation (C.K.); a senior research fellowship from the Council for Scientific and Industrial Research (R.S.); Foundation Voir et Entendre (C.Z.), Ville de Paris and Rgion Ille de France; RP Fighting Blindness (UK)(A.R.W.), Fight For Sight (UK) (A.D.B.,S.S.B.,A.T.M., D.S.M.,A.R.W.), Moorfields Eye Hospital NIHR BRC for Ophthalmology (A.D.B.,S.S.B.,A.T.M.,D.S.M.,A.R.W.), Special Trustees of Moorfields Eye Hospital (A.D.B., S.S.B.,A.T.M.,D.S.M.,A.R.W.).

The full list of collaborators and organizations is available in the PDF.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Massachusetts Eye and Ear researchers discover elusive gene that causes a form of blindness from birth [ Back to EurekAlert! ] Public release date: 29-Jul-2012
[ | E-mail | Share Share ]

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
61-705-734-170
Massachusetts Eye and Ear Infirmary

BOSTON (July 29, 2012) Researchers from the Massachusetts Eye and Ear Infirmary, The Children's Hospital of Philadelphia, Loyola University Chicago Health Sciences Division and their collaborators have isolated an elusive human gene that causes a common form of Leber congenital amaurosis (LCA), a relatively rare but devastating form of early-onset blindness. The new LCA gene is called NMNAT1. Finding the specific gene mutated in patients with LCA is the first step towards developing sight-saving gene therapy.

LCA is an inherited retinal degenerative disease characterized by reduced vision in infancy. Within the first few months of life, parents usually notice a lack of visual responsiveness and unusual roving eye movements known as nystagmus. LCA typically involves only vision problems, but can be accompanied by disease in other organ systems in a minority of patients. LCA is a common reason children are enrolled in schools for the blind.

"The immediate benefit of this discovery is that affected patients with mutations in this new LCA gene now know the cause of their condition," said Eric Pierce, M.D., Ph.D., co-senior author and director of the Ocular Genomics Institute at Mass. Eye and Ear. "Scientists now have another piece to the puzzle as to why some children are born with LCA and decreased vision. The long-term goal of our research is to develop therapies to limit or prevent vision loss from these disorders."

NMNAT1 is the 18th identified LCA gene. The gene resides in a region that was known to harbor an LCA gene since 2003, but the specific disease gene has been undiscovered until now. These findings will be published on July 29 in the online edition of Nature Genetics.

To identify NMNAT1, scientists performed whole exome sequencing of the family of two siblings who initially presented for evaluation of LCA but who had no mutations in any of the known LCA genes. Being seen by a multi-disciplinary team that took the case from careful clinical characterization to genetic testing to the research laboratory was an essential ingredient for success.

"By using whole exome sequencing, we found a mutation in a gene that no one could have predicted would be associated with LCA," said Dr. Pierce.

"Whereas most of the known LCA genes involve dysfunction of retinal ciliary proteins necessary for light detection in the eye, NMNAT1 is uniquely distinguished by being the first metabolic enzyme linked to LCA," said Marni J. Falk, M.D., co-first author and Clinical Geneticist at The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.

Having found a mutation in NMNAT1 in this one family, the investigators next asked if mutations in NMNAT1 also cause disease in other patients with LCA. Screening of 284 unrelated patients with LCA from the United States, England, France and India allowed them to identify 13 other patients with mutations in NMNAT1 as the cause of their disease.

Drs. Falk, Pierce and colleagues also studied how the identified mutations in NMNAT1 affect the function of the NMNAT1 protein, and thus may cause dysfunction and death of the light sensitive photoreceptor cells in the retina. Working together with Eiko Nakamaru-Ogiso, Ph.D., in the Department of Biochemistry and Biophysics at The University of Pennsylvania, they found that mutations in NMNAT1 appear to decrease the ability of the NMNAT1 protein to produce NAD+, a key mediator of cellular signaling and energetics.

Early treatment for patients with NMNAT1-related LCA could be especially beneficial.

Researchers found that all but the youngest patient with NMNAT1 mutations had damage to the macula, the center of the retina that is needed for central vision. "This 4-year-old girl who doesn't have central vision loss yet can possibly benefit substantially if we can devise a therapy for her NMNAT1-mediated LCA that prevents her from developing severe central vision loss," Dr. Pierce said.

This study is an example of the multidisciplinary collaboration among the three institutions, using exome sequencing to discover genes involved in inherited diseases caused by mutations of a single gene. "With the robust database and pipeline that we have developed, we have analyzed more than 300 whole exomes of patients and families with single-gene diseases," said Dr. Xiaowu Gai, co-senior author and director of the Center for Biomedical Informatics at Loyola University Chicago Stritch School of Medicine. "We are following up on a number of strong candidate genes. We are sequencing many new samples and expect similar exciting discoveries for other diseases."

###

About Massachusetts Eye and Ear

Mass. Eye and Ear clinicians and scientists are driven by a mission to find cures for blindness, deafness and diseases of the head and neck. After uniting with Schepens Eye Research Institute in 2011, Mass. Eye and Ear in Boston became the world's largest vision and hearing research center, offering hope and healing to patients everywhere through discovery and innovation. Mass. Eye and Ear is a Harvard Medical School teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships. Internationally acclaimed since its founding in 1824, Mass. Eye and Ear employs full-time, board-certified physicians who offer high-quality and affordable specialty care that ranges from the routine to the very complex. U.S. News & World Report's "Best Hospitals Survey" has consistently ranked the Mass. Eye and Ear Departments of Otolaryngology and Ophthalmology as top five in the nation. Mass. Eye and Ear is home to the Ocular Genomics Institute which aims to translate the promise of personalized genomic medicine into clinical care for ophthalmic disorders. For more information about life-changing care and research, or to learn how you can help, please visit MassEyeAndEar.org.

Grant support:

This work was supported by grants from the National Institutes of Health [RO1-EY12910 (E.A.P.), R03-DK082446 (M.J.F.), R01-GM097409 (E.N-O), P30HD026979 (M.J.F.,R.X.) and P30EY014104 (MEEI core support)]; the Foundation Fighting Blindness USA (I.A.,A.D.B.,E.L.B.,S.S.B.,Q.L.,A.T.M., D.S.M.,E.A.P., J-A.S.,S.M-S., A.R.W.); Rosanne Silbermann Foundation (E.A.P.); Penn Genome Frontiers Institute (E.A.P, X.G.); Institutional Fund to the Center for Biomedical Informatics by the Loyola University Stritch School of Medicine (X.G.); the Foerderer Award for Excellence from the Children's Hospital of Philadelphia (M.J.F. and X.G.); The Angelina Foundation Fund from the Division of Child Development and Metabolic Disease at The Children's Hospital of Philadelphia (M.J.F.); The Clinical and Translational Research Center at The Children's Hospital of Philadelphia (UL1-RR-024134) (M.J.F. and E.A.P.); the Department of Biotechnology, Government of India and the Champalimaud Foundation, Portugal (C.K); the Hyderabad Eye Research Foundation (C.K.); a senior research fellowship from the Council for Scientific and Industrial Research (R.S.); Foundation Voir et Entendre (C.Z.), Ville de Paris and Rgion Ille de France; RP Fighting Blindness (UK)(A.R.W.), Fight For Sight (UK) (A.D.B.,S.S.B.,A.T.M., D.S.M.,A.R.W.), Moorfields Eye Hospital NIHR BRC for Ophthalmology (A.D.B.,S.S.B.,A.T.M.,D.S.M.,A.R.W.), Special Trustees of Moorfields Eye Hospital (A.D.B., S.S.B.,A.T.M.,D.S.M.,A.R.W.).

The full list of collaborators and organizations is available in the PDF.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-07/meae-mea072512.php

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CYCLING ACTIVISTS ARRESTED

Some cycling activists scuffled with police officers during the Olympics opening ceremony and more than 100 people were arrested, authorities said.

The cyclists were members of a monthly cycling event called "Critical Mass" that normally passes through the area, but a police order had prohibited the group from traveling into the Olympic Park area in east London during Friday night's opening ceremony.

Dozens of cyclists were blocked by police vans from proceeding, Scotland Yard said.

Two groups of protesters were arrested on suspicion of breaching protest conditions and causing a public nuisance, Scotland Yard said.

___

EDITOR'S NOTE ? "Eyes on London" shows you the Olympics through the eyes of Associated Press journalists across the 2012 Olympic city and around the world. Follow them on Twitter where available with the handles listed after each item, and get even more AP updates from the Games here: http://twitter.com/AP_Sports

Source: http://news.yahoo.com/cycling-activists-arrested-060819756--oly.html

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Jesse Jackson Jr. in Mayo Clinic for depression

ROCHESTER, Minn. (AP) ? Illinois Congressman Jesse Jackson Jr., whose whereabouts haven't been disclosed since he mysteriously took a medical leave several weeks ago, is being treated for depression at the Mayo Clinic in Rochester, Minn., according to a statement Friday from the hospital.

Jackson is undergoing an extensive inpatient evaluation for depression and for gastrointestinal issues, according to the statement, which also provided the first details about his medical condition. But it provided no details about where the congressman, the son of civil rights leader Jesse Jackson, had previously been staying.

"Further information will be released as Congressman Jackson's evaluation proceeds," the statement said, adding that he and his family were "grateful for the outpouring of support and prayers that have been received throughout his care."

Jackson went on leave June 10, though his office didn't disclose it until weeks later and has been mum on details ever since. Initially, his office said Jackson was being treated for exhaustion. But his staff later said Jackson's condition was more serious and required inpatient medical treatment. They also said Jackson has been grappling with emotional issues.

Under mounting pressure from fellow politicians and others, his office released a statement last month from his unnamed doctor saying Jackson was receiving intensive medical treatment at a residential treatment facility for "a mood disorder."

The timing of the leave has raised questions, in part because Jackson is facing an ethics investigation in the U.S. House connected to imprisoned former Illinois Gov. Rod Blagojevich.

The House Ethics Committee is investigating allegations that Jackson was involved in discussions about raising money for Blagojevich's campaign in exchange for the then-governor appointing him to President Barack Obama's vacated U.S. Senate seat. Blagojevich is serving a 14-year prison sentence for corruption.

Jackson was not charged and has repeatedly denied wrongdoing.

Source: http://news.yahoo.com/jesse-jackson-jr-mayo-clinic-depression-023156751.html

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Saturday, July 28, 2012

"My Future Hong Kong" drawing competition award presentation ...

Released on July 28th, 2012

More than 3,000 members of the public as well as primary and secondary school students participated in the ?My Future Hong Kong? drawing competition organised by the Planning Department and City Gallery, and supported by the Hong Kong Society for Education in Art, to illustrate their vision of the future through painting.

The award presentation ceremony, in which 48 participants and 2 schools received awards, was held at the City Gallery in Central today (July 28).

Officiating at the ceremony, the Director of Planning, Mr Jimmy Leung, said he was encouraged by the fervent response to the competition.

?The drawing competition is intended to encourage the public to illustrate their ?dream homeland? and the future of the city using imagination and creativity, so as to share their vision of Hong Kong as the ideal place to live,? Mr Leung said.

The competition comprised three sections, namely the primary school section, secondary school section and open section, with the respective themes of ?My Dream Homeland?, ?Ideal Green City? and ?Impressive Hong Kong?. A champion and 15 outstanding awards were selected for each section. Awards for active participation were also given to the primary and secondary schools with the highest number of submissions.

The winning entries will be exhibited in the City Gallery from August to mid-September.

Located at 3 Edinburgh Place, Central, the City Gallery will be officially opened in the latter half of August. It will be the first permanent planning and infrastructure gallery in Hong Kong. Occupying five storeys with a floor area of more than 3,200 square metres, the gallery will offer a host of interactive exhibits to showcase the uniqueness of Hong Kong past and future, as well as share with the public the vision for city planning and infrastructure projects.

Source: http://asiarelease.asia/my-future-hong-kong-drawing-competition-award-presentation-ceremony-held-with-photos/

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Plastic Surgery in Costa Rica - Free Article Directory


Health and Fitness | Weight Loss | * Written by Dr.Oscar Su?rez | Friday, 27 July 2012 02:06 | Word Count: 499

Have you ever felt that your body is not the way you want it to be? Has there been any part of it that you would like to change? The good news is that nowadays most changes are possible when it comes to the human body! The only thing is, however, that you must be careful where you go to do these changes. Plastic surgery can be very dangerous if you are in the wrong hands. For that, I recommend Costa Rica plastic surgery. Cosmetic surgery in Costa Rica is very safe, and even though you get great quality procedures, you pay a lot less, and the plastic surgeons are very professional! But still, you must be careful about choosing the right place. Keep reading if you want some tips on how to choose the right place to get plastic surgery!

One important thing you should do is to investigate. The web is a great place for that. If you find a clinic where you think you could get you cosmetic surgery done, Google it! Find out about the quality of their work, how much experience they have, and if possible, what others think about them. All that will help you to come to a conclusion whether the clinic is good enough or not. Plastic surgery in Costa Rica usually is of good quality, but it?s always good to make sure. Cosmetic surgery is very important, so you must take all this information into consideration.

Another aspect that you should take into account is the salubrity of the clinic. This is very important because if the place is not clean enough, you could get an infection. Therefore, when you are trying to decide, walk into the clinic and look around. Analyze whether there are alcohol dispensers (which most clinics and hospitals have in Costa Rica). Do the doctors use rubber gloves? Are the janitors cleaning up? Do the doctors sterilize the tools? Those are the questions that must be answered.

Last, but not least, socialize with the plastic surgeon that will perform the cosmetic surgery. Get to know his/her attitude. Most people in Costa Rica are friendly, but there are exceptions, and you must make sure that this person is not one of them. If you are wondering why, the reason is that this person is going to have your life and health in his/her hands, so it is a good idea to know that s/he will care enough.

To conclude, cosmetic surgery is possible, but you must think about where to do it. Plastic surgery in Costa Rica is a great option. Costa Rica plastic surgeons are great, and you pay less. However, you must make sure that the clinic where the procedure will be done has been well investigated (by you), that it is clean, and that the plastic surgeon is friendly enough. Follow these three tips and you will see that the clinic you choose will be the best option of all, so choose well, and enjoy the changes!

Our Cosmetic Surgery in Costa Rica |Plastic Surgeon Costa Rica are being offered by a professional team whose primary goals are patient safety and natural appearing results.

Article Source: Article Directory - http://www.freearticleforyou.com

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Author of this article: Dr.Oscar Su?rez.

Dr.Oscar Su?rez joined FAFY - Free Article For You on Thursday, 12 July 2012.

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Source: http://www.freearticleforyou.com/Health-and-Fitness/Weight-Loss/plastic-surgery-in-costa-rica-how-to-choose-the-best-place.html

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?M0RWmn87 | Activity | Blogs

??(Reporter correspondent Fan Hua Wang Yan) yesterday, good news came from the Municipal Finance Bureau, the city?s financial sector from January to June this year to tackle tough, successful completion of the goal of more than half the time, more than half of the task ?to complete the total fiscal revenue 40.777 billion yuan, up 15.5 percent; local general budget revenue of 21.061 billion yuan, an increase of 24.5% and 56.4% of the annual budget. The grim situation of income to the service management revenue this year by the complex and volatile economic situation and the macro-control policies affect the city?s economy has shown a lower opening and steady advance, the development trend of the trend for the better. Reflected in the fiscal economic indicators, industrial and commercial tax short closing, and key industry revenue does not increase anti-drop,abercrombie france, financial income decreased quality of economic operation is facing the risk of excessive growth trend. Faced with the grim situation in the organization of income, the municipal government held the city ?fully grasp and implement, to ensure that pairs more than half of the mobilization meeting. The city tax department immediately after the action. City,jordan, State, and local tax departments to improve tax collection and management of information technology as a breakthrough, vigorously promote online the Tax (charge) and online invoicing system, and enhance the quality of tax collection. Finance,abercrombie, land tax, the Joint Housing Authority department of real estate transactions and tax collection system network, assess the price of housing transactions. Exist for the travel tax levied in the phenomenon, the departments of finance, taxation,abercrombie, traffic police,?????????, the CIRC will travel tax collection and management query system and the traffic police, insurance companies, networking, listed in the vehicle by the traffic police department, the factual aspects of the travel tax check in order to achieve ?first after tax of hanging, the first after-tax check ?. At the same time,abercrombie pas cher, the application of tax collection and analysis and risk management of the national and local tax departments, corporate income tax assessment,????, tax administration and tax services and other information systems of large enterprises to actively carry out tax economic analysis and tax sources investigation, increase monitoring efforts to assess to income revenue management implemented. Cultivate new growth points to the policy income In addition, seriously implement the structural tax reduction policy, and to honor the landing of the good to promote regional projects, to promote industrial restructuring,???????, to encourage independent innovation and accelerate the development of SMEs and the financial and taxation preferential policies, adhere to policy to income, the enhancement of training the new growth point of the tax revenue. The first half of the year, the department of municipal finance and the City of Industry and Information Committee to study the introduction of a number of policy measures to accelerate development to support the city?s industrial,abercrombie france, clear the 2012-2016 Urban Financial cumulative arrangements to support industrial development, capital of four billion yuan. At the same time, implement the municipal government to implement province in steady growth in the decision-making to ensure the steady and rapid growth of the city?s economic measures recommended in the first half, has issued 697 million yuan of capital construction funds to complete the secondary road network in 2012 of the city?s 330 million yuan project capital raised allocated to fight for a place to bond the amount of funds of 920 million yuan. The same time, the fight of 60 million yuan for provincial key town grant funding arrangements for the project construction funds of 300 million yuan to support construction of small towns. Arrangements for affordable housing, public rental housing construction funds of 722 million yuan. The stimulation of investment is not weakened, effectively promoting steady and rapid growth of the city?s economy. Spending accounted for 76.2 percent of the people?s livelihood and the expenditure side, the reporter learned that the first half of the city?s general budget expenditure was 25.829 billion yuan, an increase of 21.1 percent, 57.2 percent of the budget. Among them, the people?s livelihood expenditure was 19.673 billion yuan, an increase of 20.9 percent, accounting for 76.2% of the general budget expenditures,air jordan, accounting for the comparative prior year period increased by 2.4 percentage points. Fund budget revenue of the city?s 19.458 billion yuan, an increase of 1.29 times; Fund budget expenditure was 18.299 billion yuan, an increase of 1.11 times. Author: Fan Hua Wang Yan

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Dong Xiaosheng said Jen originally in Guangzhou

Source: http://w.buytrendyclothes.com/activity/p/10387/

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Friday, July 27, 2012

'The Master' Moves Up, 'Killing Them Softly' Pushed Back In Dailies

Do you want the good news or the bad news first? The good news is that "The Master" has been moved up to September. The bad news is that we have to wait longer for "Killing Them Softly." Also, find out about moonshine and learn how to make meth in today's Dailies! » The next [...]

Source: http://moviesblog.mtv.com/2012/07/27/the-master-killing-them-softly-change/

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(7 weeks pregnant)? - Three years, one stone then home

A hop back in time to ?

Sunday, June 3, 2012

Oh wow, the past three weeks have been a nightmare of tiredness and nausea. No amount of sleep or ginger ale seem able to relieve either. I found the first three months of my last pregnancy extremely hard-going, much tougher than the following six months, and it seems that this one is set to be the same. I can?t get my brain or body going and am counting down the days?until the rock-star feeling of the second trimester. Please let me have that rock-star feeling again! Minus the cankles and the massive boobs would be nice though.

I find myself looking back to my first pregnancy quite a lot but my main memories of the initial three months are trying to make a quick but discreet dash to the loo to throw up every ten minutes. After narrowly missing my boss? shoes last week, I think it?s fair to say that discretion has gone out of the window already ? ?Rachel, do you have something to tell me?? Some things are just so hard to hide, aren?t they?

I nervously made my way to see my gynecologist for the first scan on Tuesday. Even after a positive pregnancy test, I found myself still unwilling to believe the result without his confirmation. But, at 6 weeks and 2 days, I saw my little 3.5mm baby and it?s ever so tiny heartbeat on the screen in front of me. It was an absolutely joyous moment and now it?s finally starting to sink in that, all things going well, we?re going to be a family of four in 2013.

Now I just need to find an extra boost of energy to see me through until the morning sickness and tiredness abates. It?s CK that I feel most sorry for as I find myself having to sit down more often rather than playing with him. But we?ve been out for longer walks which he seems to like ? I?m finding that walking at a slow but steady pace and filling my lungs with fresh, Swiss air is doing me the world of good and keeping CK entertained without me having to exert too much energy. Shame the weather has made a turn for the worse this week.

My next scan is a mere two and a half weeks away. I find it very reassuring to have them so frequently. At any point in time, I?m four weeks away at the most from knowing that something is wrong. Maybe the Swiss are a little cautious compared to the Brits but when it comes to the health of my unborn child, I?m so thankful for it. Plus, I get to build up quite a gallery even before the little one is born.

So now I must bid you farewell so I can rush off and down another glass of ginger ale and take a nap. Oh what an exciting life I lead ? but I wouldn?t have it any other way.

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Source: http://threeyearsandonestonethenhome.com/2012/07/26/sevenweekspregnant/

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Greek prime minister meets austerity inspectors

ATHENS, Greece (AP) ? Greece's prime minister is meeting international austerity inspectors to outline new harsh cost-cutting reforms, without which the country would likely lose the rescue loans that are keeping it afloat.

Antonis Samaras, whose conservative-led coalition came to power just over a month ago, is under intense pressure to implement and expand on his predecessors' reform pledges.

The meeting in Athens Friday comes a day after EU Commission President Jose Manuel Barroso urged Samaras to "deliver, deliver, deliver" on the promises.

European Union, International Monetary Fund and European Central Bank officials started a new scrutiny of Greece's austerity program this week.

The debt-crippled country has been surviving on international bailouts since May 2010. To secure them, it imposed deeply resented spending cuts, slashing incomes and salaries while hiking taxes.

Source: http://news.yahoo.com/greek-prime-minister-meets-austerity-inspectors-084314467--finance.html

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Thursday, July 26, 2012

How I was Cory Booker?d into submission (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

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PFT: Chad Johnson predicts 'monster' season

Panthers Rivera FootballAP

Panthers center Ryan Kalil rallied the fan base with a full-page ad in the Charlotte Observer declaring that the Panthers will be the Super Bowl XLVII champions.? (One person pointed on Twitter that Kalil misspelled ?Packers.?)

Ultimately, Kalil was behaving like a fan, and that?s the kind of behavior the fans love.

His coach loves it, too.

?I?m right behind [Kalil],? Ron Rivera said, via Ian Rapoport of NFL Network.? ?I feel the same way.? This is a group of men who, if they work hard and put it on themselves, the sky can be the limit.? But, we?ve got to go out and do it now to become the football team that has a chance to win every Sunday.?

Rivera thinks it?s important for players to possess that kind of enthusiasm.

?[I]f we don?t have 53 guys with that attitude in our locker room right now, then we gotta find the guys that want it,? Rivera said.? ?We don?t know what?s going to happen.? But we gotta come out and play and play hard and do everything we can to win that Super Bowl and they have the right attitude, that right mental frame of mind and that?s what Ryan?s done.? Ryan?s put it out there, like, ?Hey.? This is my mental outlook, this is my frame of mind.? This is what I want, so let?s go out and get it.??

Linebacker Jon Beason agrees.? ?You can?t put the carriage before the horse,? Beason told Rapaport.? ?But I love it.? I?ve been saying that for a while now.? The first step to reality is kinda the belief.? Having that confidence in what you?re doing, and now it?s all about the preparation.?

So why am I celebrating Kalil when in the past I?ve criticized guys like Rex Ryan and Mike Vick for doing pretty much the same thing?? With a contending team, that kind of talk comes off as presumptuous and crass.? With a team not widely viewed as a Super Bowl contender, talk like that demonstrates and develops the kind of confidence that can make an otherwise fringe team contend.

In this context, it comes off not as arrogance but as an expression of determination.? The kind of determination that, not long ago, simply didn?t exist in Charlotte.

Kalil will have a chance to elaborate or to backtrack on Thursday, when he appears on the final PFT Live before we take a break in deference to something called the Olympics.? I?m willing to predict he won?t be backtracking.

Source: http://profootballtalk.nbcsports.com/2012/07/25/chad-johnson-predicts-a-monster-season-for-himself/related/

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Paleo Series Part II: Paleo for the Whole Family | the other baby blog

This is the second installment of a four-part series on the popular Paleo way of eating and lifestyle from a mama?s perspective. You can find Part I here. Although Kate is not a medical professional or nutritionist, she?ll share her thoughts and experiences of implementing Paleo in her household.?

Paleo: a simple, whole foods way of eating that focuses on meats, vegetables, fruits, and fats. It is also a lifestyle that places importance upon restful sleep, functional movement exercise, and interacting with and enjoying the outdoors.

Kale/Spinach Smoothie: A regular in our household

WARNING: Reading the following might result in improved health, more energy, and a desire to swing from a tree branch. Oh, and your kids will benefit as well!?

This morning my husband, my mother-in-law, daughter, and I shared a simple breakfast of scrambled eggs,?saut?ed?fresh squash from the farmer?s market, and cups of coffee for the adults (no cream/sugar.) Vivi wasn?t crazy about the squash, but tasted it several times, examined the texture, and eventually decided to enjoy her eggs without. She still seemed hungry, so I quickly blended up some raw kale, frozen fruit, coconut milk, and water. She gulped down three small cups.

This meal, while simple enough, met the complex and diverse needs of all of us. The low-glycemic index of the squash and eggs satisfied my diabetic mother-in-law. My husband, who seems to be always trying to slim down and get a six-pack (I support ya, sweetie!), appreciated the low-carb aspect of the meal, but felt satiated by the coconut oil used to cook the squash. And my daughter? Well at 16 months, a meal like this is normal, tasty, and?unbeknownst?to her,?nutritious. When we eat Paleo as a family, every meal is a home run: nutritious, tasty, and satisfying.

Paleo is a total change of lifestyle and can be tough enough for adults. So often, there might be one person in a family eating Paleo, while the rest stick to what?s familiar. I want to assure you that it doesn?t have to be this way! But inevitably, there are usually two questions floating around when you mix Paleo and kiddos:

  • What does Paleo eating look like for babies, toddlers, and older children?

Paleo eating for kids is pretty simple: if you?re eating Paleo, they can eat all the same things as you. No more cooking two meals and loading the shopping cart up with ?kid-friendly? options!

Babies and toddlers will naturally gravitate toward a more veggies/fruit/fat based version and less meat. My daughter will often refuse meat for a week at a time, while devouring everything else. Paleo and baby-led weaning naturally go hand in hand: think soft pieces of fruit and vegetables, egg yolks, homemade broths, and slow-cooked meats that are easy to chew for the baby who is at least 6 months old. Don?t forget the breastmilk?your cavewoman ancestors would be proud!

Independent toddlers will relish the opportunity to eat what their parents do, rather than something else that looks and tastes totally different. Having options to choose from will allow these headstrong babes to feel in control.

Older children might be a bit more difficult to get on board if they haven?t eaten this way previously. The best thing you can do is to only keep nutritious options in your home, make Paleo meals, and don?t worry about the rest. Kids are so?resilient?and adaptable: give them the chance to make healthy choices, and I think you will be surprised.

  • And is Paleo eating even healthy for kids??

Immediate answer: YES! Do you know anyone who has ever become obese/sick/diseased while eating plenty of vegetables, fruits, and high-quality meats, eggs, fats, and fish? Children thrive on this type of diet, and you may have seen something similar prescribed for kids with Autism Spectrum Disorder, the GAPS diet. ?The Paleo way of eating provides such a varied, nutrient-rich diet that allows a parent to relax about food choices. No need to worry if your little one is getting enough of one nutrient or another because, most likely, they are getting them all and in ample?quantities.

However, there are two big issues that concern many parents: no grains and no dairy. Aren?t kids supposed to have both for the fiber and nutrients (grains) and the calcium and vitamin D (dairy)?

The short answer is this: kids will get all of the above nutrients from a Paleo diet. Vegetables and fruit provide ample fiber (yay poop!), leafy greens and nuts take care of calcium, and vitamin D can be sourced naturally from a short play session outside (step away from the Wii, my friends.) Instead of cow?s milk, my daughter drinks plenty of water, kale/spinach shakes, and an occasional cup of straight coconut milk. I?m pretty positive (at least 99% sure) that she is not only meeting the government?s snazzy RDA (recommended daily amount) of nutrients, but blowing those old-school recommendations out of the water. But if you want scientific charts, medical studies, etc.,?and not the word of some random mama on the internet, you can?t do wrong with reading a little Robb Wolf.

Kids on a Paleo?diet are healthy, happy, don?t experience sugar-induced mood swings, and will typically sleep pretty soundly. If the warm and fuzzy image of your kids growing lean and strong on whole, nutrient-dense foods and plenty of play outside has you clamoring for more info, take a gander at these oh-so-helpful resources:

Books

  • Family-friendly recipes, ?games? (OK, exercises) for the whole family, and great information:?Everyday Paleo by Sarah Fragoso
  • Looking for the science behind all this? (I?m with ya, sister?or brother.) Then look no further than biochemist, research nerd Robb Wolf?s book?The Paleo Solution.?

Blogroll

Who doesn?t love a good blog? (Ahem, TOBB.) Feast your eyes on these great internet writers:

And please, by all means, shoot your questions my way, and I?ll do my best to either answer them or point you in the right direction. Now go whip up a spinach smoothie, and get with it!

When Kate is not sharing a coconut-kale smoothie with her little one or planning/throwing together a Paleo meal, she enjoys writing about women?s issues, endlessly (virtually) redesigning her place a la Pinterest, and chatting with friends over coffee.?

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Source: http://theotherbabybook.wordpress.com/2012/07/26/paleo-series-part-ii-paleo-for-the-whole-family/

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Zagat: 10 Neighborhood Gems of San Francisco

While celebrity-backed flagships and hipster havens may get a lot of attention, there are literally hundreds of other off-the-beaten path neighborhood restaurants in San Francisco serving up high-quality, Californian-fresh food in inviting, if not splashy, digs. Check out some of our favorite off-the-beaten-path restaurants (including reader picks and recommendations from some local food bloggers) in the slideshow below, and let us know your under-the-radar gems.

[Also see: SF's 5 Coolest Hot Dog Spots]

Noe Valley/Glen Park: La Ciccia
It may be hidden in the hinterlands straddling the sleepy 'hoods of Noe Valley and Glen Park, but La Ciccia, a cozy family-run Sardinian spot, is Grand Central on any given night. Local writer Marcia Gagliardi (aka The Tablehopper) calls it the quintessential neighborhood gem. "It's on a quiet street, totally unpretentious and so very delicious." But the piece of resistance, Gagliardi adds, are "the owners" (she's the front of house, he's the chef and wine wizard), who "are so welcoming, they exhibit such true hospitality." "And wow" she adds, "what a rocking wine list." Just know this -- you won't recognize much on the menu or the regional wine list (no fettuccine Alfredo and Chianti here). And don't bother showing up without reservations -- it's a small space. Read more about Gagliardi has to say about La Ciccia here.

The Details: 291 30th St.; 415-550-8114

[Also see: The 10 Most Awkward Dining Moments]

Bernal Heights: Piqueos
Star chefs like Gaston Acurio and others hog the Lima-light, but reader Helen Simon recommends Piqueos, an unpretentious, reasonably priced Peruvian squirreled away in bite-sized Bernal Heights storefront where Carlos Altamirano (also of Mochica and La Costanera) serves up "fantastically flavored" ceviches, crudos and other small plates plus two types of paella.

The Details: 830 Cortland Ave.; 415-282-8812

[Also see: Sipping for Less: Half-Priced Wine Nights in the Bay Area]

Pacific Heights: Sociale
Reader Nancy Kivelson, who works for The Kivelstadt Vineyard & Qualia Wines, writes in to say tell us that her beloved neighborhood gem is "hidden" Pac Heights haunt Sociale, located "down a little alley with outdoor seating all year-round," where the owner always "greets regulars" and the kitchen turns out Northern Italian specials such as "fresh pastas with intriguing sauces" at "prices to fit a nice neighborhood bistro" but "of a much higher caliber." She's not alone -- Sociale is packed day and night.

The Details: 3665 Sacramento St.; 415-921-3200

[Also see: Bay Area's 5 Best Food Trucks]

Russian Hill: Luella
You'll find Luella mostly packed mostly with locals -- after all, parking is impossible and what self-respecting San Franciscan is going to hop a cable car to go out to dinner (the car stops right out front)? Still, Cooking with Amy blogger Amy Sherman reveals its one of her favorite spots with a "great friendly vibe" and great classics like "crispy polenta fries and short-rib lasagna that never come off the menu." Wanna act like a real regular? Sherman suggests you ask your waiter about the "off the menu specials like the divine marrow burger."

The Details: 1896 Hyde St.; 415-674-4343

[Also see: Top Chef Masters Season 4: Whose Food Lives Up To the Hype?]

Mission: Blue Plate
There's no shortage of hipster restaurants in the city, and Blue Plate has all the usual elements: PBR, adult mac 'n' cheese and tattooed staffers. Still, the low-key spot (look for the vintage EAT sign) serving up gussied-up, sustainably sourced New American comfort food, along with serious wines, is that proverbial neighborhood spot for a certain foodie demographic living on the south side of the city. Bonus points for its secret garden.

The Details: 3218 Mission St.; 415-282-6777

[Also see: First Look: Amber Dhara Opens in the Mission]

Richmond: Chapeau!
When tourists want French food, they usually head Downtown to the better known addresses, but locals who live west of Van Ness know the real deal can be had at Chapeau! where gregarious chef/owner Philippe Gardelle still regales les dames with kisses on both cheeks, les monsieurs with a firm handshake and everyone with textbook bistrot classics and well-priced vins including a can't be beat early-bird and weekday prix fixe. This long-running venture used to be in an even more obscure Richmond locale, but now it's a firmament on the Clement Street drag where you can walk off your cassoulet.

The Details: 126 Clement St.; 415-750-9787

[Also see: Susan Feniger on Her New Cookbook, Her Love of Street Food and More]

Dogpatch: Piccino
Most city folks are just getting word of this far-flung Dogpatch neighborhood, but the local artists, artisans and other free-minded residents who've been turning around this up-and-coming neighborhood off Third Street have long depended on Piccino?for sustenance. Even since moving to its much larger Yellow Building digs, the Cal-Italian, which turns out delightful ingredient-driven, thin-crust pizzas, salads and one helluva a meatball, gets packed to the gills most hours of the day.

The Details: 1001 Minnesota St.; 415-824-4224

[Also see: Neighborhood Gems: A Look at Hidden Standbys Across the U.S.]

North Beach: The House
A welcome respite in the land of red-sauce restaurants and red-light strip clubs, The House, this low-key Asian-fusion beckons North Beach locals and anyone else tired of Italian to its tiny blonde wood digs where pioneering chef Lary Tse's turns out colorful, architectural creations like miso-marinated cod and roasted unagi, proffered by a skillful, yet friendly staff. It often gets cramped and noisy at night, but things are less hectic at lunch.

The Details: 1230 Grant Ave.; 415-986-8612

[Also see: Preview: Rich Table Almost Set in Hayes Valley]

Outer Sunset: Outerlands
It's truly located on the outermost edge of the city and largely dominated by surfer types in the daytime who carbo-load up on the incredibly fresh-baked bread and hearty sandwiches, but there's way more going on at Outerlands, a stealth wood-lined neighborhood haunt in the Outer Sunset where come nighttime, former Coi vet Brett Cooper crafts progressive ingredient-driven Californian dinners, which can be matched with farm-fresh cocktails. No reservations means long lines in the fog, though a scheduled winter expansion that will double the amount of seating should help alleviate some of that. In the meantime, just put your name of the list, grab a drink and deal with it. P.S. lunch is now served via table service.

The Details: 4001 Judah St.; 415-661-6140

[Also see: Taste Test: McDonald's Chocolate Chip Frappe]

Noe Valley: Firefly
Most people generally don't venture this high up on Noe Valley's 24th Street unless they're heading to the park with their kid or dog, but Brad Levy's quirky eclectic neighborhood fixture Firefly has consistently been packing in the locals (and foodies who do their homework) for almost 19 years. There's plenty to lure them -- the quaint decor, the friendly service and the years-ahead-of-its-time locally sourced, global comfort menu that takes equal care of vegetarians, gluten-intolerants and omnivores alike.? Oh, and did we mention a crazy low three-course early bird prix fixe (Sunday-Thursday), the fried-chicken-of-your-dreams and Jewish holidays dinners that beat the pants of your Bubbe's?

The Details: 4288 24th St.; 415-821-7652

[Also see: Where Do You Stand on "Tweezer Food?"]

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Source: http://www.huffingtonpost.com/zagat/san-francisco-neighborhood-restaurants_b_1698940.html

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Euro rises on ECB talk, earnings buoy Dow

NEW YORK (Reuters) - The euro rose against the dollar for the first time in six days on Wednesday after suggestions that European policymakers will consider new ways to tackle the region's debt crisis, while U.S. earnings supported blue-chip stocks.

Higher 2012 profit forecasts from big manufacturers Caterpillar and Boeing and an outlook for quarterly revenue growth from chipmaker Broadcom helped to offset news of an unexpected drop in new U.S. home sales.

On Wall Street, the Dow snapped a three-day losing streak and the S&P and Nasdaq slipped only modestly, even as shares of Apple Inc, the world's most valuable publicly traded company, fell 4.3 percent to $574.97 after it posted a rare miss in revenue late on Tuesday.

"I'm encouraged investors are taking the Apple news pretty well," said Jack Ablin, chief investment officer at Harris Private Bank in Chicago.

Ablin said after a more than 40 percent rise in Apple shares this year, Wednesday's drop is but a speed bump, adding that the raised outlooks from Dow components Caterpillar and Boeing "is a huge positive for the market."

The Dow Jones industrial average rose 58.73 points, or 0.47 percent, to 12,676.05. The S&P 500 Index dipped 0.42 point, or 0.03 percent, to 1,337.89. The Nasdaq Composite Index fell 8.75 points, or 0.31 percent, to 2,854.24.

The euro rose 0.8 percent to $1.2156, although the outlook remains weak and it remained only just above a two-year low of $1.2042 hit Tuesday.

A member of the European Central Bank's Governing Council, Ewald Nowotny, said there were arguments for giving Europe's new permanent rescue fund a banking license, enabling it to borrow unlimited central bank money and boosting its capacity to prevent the euro zone debt crisis from spreading.

Analysts said the market may have put too much emphasis on the comments, given other ECB officials' opposition to the idea. Investors would likely sell into the euro's rally, the analysts said.

"The market is grasping for any positive news," said Omer Esiner, chief market analyst at Commonwealth Foreign Exchange in Washington, D.C. "It adds to the already somewhat improved tone. Whether or not it lasts is the question."

Market support from central banks has been expected for weeks as economic data sags globally. Weak readings on Britain's gross domestic product and on a German business sentiment survey added to worries about slowing growth.

FED TO ACT SOON?

Top Fed officials recently spelled out what measures they might take to boost growth and hiring. Fed action could come as soon as its policy meeting next week, on July 31-August 1.

"Right now in my view it's still Fed rhetoric, but enough to keep investors confident to take risk. I don't necessarily see tangible action. I think the Fed is afraid to take action, fearful the market could shrug it off," Ablin said.

Despite a sluggish recovery and a suggestion by some analysts that the U.S. economy may already be in recession, the S&P 500 hit its highest level in 2-1/2 months last week.

The MSCI world equity index was flat on Wednesday, but has fallen 2.4 percent so far this week as concerns about the impact of Europe's problems on growth spread across the world.

U.S. dollar-denominated Nikkei futures rose 0.1 percent in choppy trading. The pan-European FTSEurofirst 300 index closed 0.07 percent lower.

Further supporting the euro, Spain and France said that a single supervisory mechanism for the bloc's banks needs to be adopted by the end of the year.

ECONOMIES SAG

The gains in the euro came despite the weak economic data from Germany and the UK, which reinforced the view that even Europe's biggest economies were being damaged by the debt crisis.

German business sentiment dropped in July for the third straight month to its lowest level in over two years, according to the latest survey by the Munich-based Ifo think tank.

British economic output also shrank much more than expected in the second quarter, hit by the euro zone debt crisis and government austerity, official data showed.

Greece was also back in the headlines with inspectors from the EU, ECB and International Monetary Fund in Athens to decide whether to keep it hooked up to a 130 billion euro lifeline or let it face default.

Three EU officials have said the team was likely to conclude Greece cannot repay what it owes, making a further debt restructuring necessary, but no decision is expected until at least September.

The benchmark 10-year U.S. Treasury note was down 3/32 in price, with the yield at 1.4008 percent after earlier rising as high as 1.44 percent. The yield hit an all-time low on Tuesday.

Gold futures rose more than 2 percent as expectations of U.S. and European monetary stimulus strengthened its appeal as an inflation hedge. Gold futures were last up 2 percent at $1,608 an ounce.

(Additional reporting Nick Olivari; Editing by Kenneth Barry and Leslie Adler)

Source: http://news.yahoo.com/global-shares-fall-intensifying-worry-over-spain-003611096--finance.html

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